[1]魏海龙,程俊文,胡传久,等.牛樟芝固态发酵产安卓奎诺尔工艺研究[J].浙江林业科技,2017,37(04):39-44.[doi:10.3969/j.issn.1001-3776.2017.04.007]
 WEI Hai-long,CHENG Jun-wen,HU Chuan-jiu,et al.Optimizing of Technology for Preparation of Antroquinonol from Antrodia cinnamomea by Response Surface Methodology[J].Journal of Zhejiang Forestry Science and Technology,2017,37(04):39-44.[doi:10.3969/j.issn.1001-3776.2017.04.007]
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牛樟芝固态发酵产安卓奎诺尔工艺研究()
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《浙江林业科技》[ISSN:1001-3776/CN:33-1112/S]

卷:
37
期数:
2017年04期
页码:
39-44
栏目:
出版日期:
2017-09-30

文章信息/Info

Title:
Optimizing of Technology for Preparation of Antroquinonol from Antrodia cinnamomea by Response Surface Methodology
作者:
魏海龙程俊文胡传久贺亮钱华李海波王衍彬邹景泉蒋云鹤
浙江省林业科学研究院浙江省森林资源生物与化学利用重点实验室,浙江杭州 310023
Author(s):
WEI Hai-longCHENG Jun-wen HU Chuan-jiuHE LiangQIAN HuaLI Hai-boWANG Yan-binZOU Jing-quanJIANG Yun-he
Key Laboratory of Biological and Chemical Utilization of Forest Resources of Zhejiang, Zhejiang Academy of Forestry, Hangzhou 310023, China
关键词:
牛樟芝安卓奎诺尔固体发酵响应面
Keywords:
Antrodia cinnamomea antroquinonol solid-state fermentation response surface methodology
分类号:
R282.71
DOI:
10.3969/j.issn.1001-3776.2017.04.007
文献标志码:
A
摘要:
对牛樟芝Antrodia cinnamomea固态发酵生产安卓奎诺尔的工艺条件进行优化。先通过单因素试验,筛选出小麦Triticum aestivum质量、相对湿度、培养温度3个主要影响参数,再应用响应曲面分析法优化。结果表明,牛樟芝产安卓奎诺尔固态发酵最佳条件为:小麦80.82 g,相对湿度58.01%,培养温度28.48℃,安卓奎诺尔的平均产量可达259.79 mg·kg-1
Abstract:
Experiments were conducted on optimizing technology for preparation of antroquinonol from solid-state fermented mycelium of Antrodia cinnamomea. Single factor experiment selected important factors such as mass of Triticum aestivum, relative humidity and culture temperature, and technology was optimized by response factor analysis. The result demonstrated that the average yield of antroquinonol reached 259.79 mg/kg with wheat of 80.82 g, relative humidity of 58.01%, culture temperature of 28.48℃.

参考文献/References:

[1] 蔡为民,金群力,蔡青松,等. 牛樟芝人工培养及活性成分与药理作用的研究进展[J]. 食药用菌,2015,23(1):17-23.
[2] Lu M,El-Shazly M,Wu T,et al. Recent research and development of Antrodia cinnamomea [J]. Pharmacol Therap,2013,139(2):124-156.
[3] 赖敏男. 台湾牛樟芝发展史及人工栽培现况[J]. 食药用菌,2017,(25)2:84-89.
[4] Lee T H,Lee C K,Tsou W L. A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata[J]. Plant Medic,2007,73(13):1412-1415.
[5] Yu C C,Chiang P C,Lu P H,et al. Antroquinonol,a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells [J]. J Nutr Biochem,2012,23(8):900-907
[6] Kumar V B,Yuan T C,Liou J W,et al. Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles [J]. Mutat Res,2011,707(1-2):42-52.
[7] Jin Q L,Zhang Z F,Lu G Y,et al. Antioxidant and DNA damage protecting potentials of polysaccharideextracted from Phellinus baumii using a delignification method[J]. Carbohydr Polym,2016,152,575-582.
[8] 夏永军,李炜疆,许赣荣. 樟芝固态发酵产品活性代谢产物分析[J]. 食品与发酵工业,2011,37(8):86-90.
[9] 张成军. 实验设计与数据处理[M]. 北京:化学工业出版社,2009.

备注/Memo

备注/Memo:
收稿日期:2017-01-27 ;修回日期:2017-05-24
基金项目:浙江省科技厅公益技术研究项目(2013C32095),浙江省农业(食用菌)新品种选育重大科技专项(2016C02057-8)
作者简介:魏海龙,硕士,副研究员,从事食用药用菌培育与加工研究;E-mail:whlwlp@163.com。
通信作者:程俊文,副研究员,从事食用药用菌活性成分加工研究;E-mail:jwchengzj@163.com。
更新日期/Last Update: 2017-08-30